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Abstract Over three decades of reverberation mapping (RM) studies on local broad-line active galactic nuclei (AGNs) have measured reliable black hole (BH) masses for >100 AGNs. These RM measurements reveal a significant correlation between the Balmer broad-line region (BLR) size and AGN optical luminosity (theR–Lrelation). Recent RM studies for AGN samples with more diverse BH parameters (e.g., mass and Eddington ratio) reveal a substantial intrinsic dispersion around the averageR–Lrelation, suggesting that variations in the broadband spectrum, driven by accretion parameters and other factors such as the cloud distribution and inclination, significantly influence the measuredR–Lrelation. Here we perform a detailed photoionization investigation of expected broad-line properties as functions of accretion parameters using AGN continuum models fromqsosed. We compare theoretical predictions with observations of a sample of 67z ≲ 0.5 reverberation-mapped AGNs with rest-frame optical and UV spectra in the moderate-accretion regime (Eddington ratioλ_Edd ≡ L/L_Edd < 0.5). The UV/optical line strengths and their dependences on accretion parameters are reasonably well reproduced by the locally optimally emitting cloud photoionization models. We provide quantitative recipes using optical/UV line flux ratios to infer the unobservable ionizing continuum. Additionally, photoionization models with universal values of ionization parameter ( $\log U_{\mathrm{H}}=-2$) and hydrogen density ( $\log n\left(\mathrm{H}\right)=12$) can qualitatively reproduce the observed globalR–Lrelation for the current RM AGN sample. However, such models fail to reproduce the observed decrease in BLR size with increasingL/L_Eddat fixed optical luminosity, implying that gas density or BLR structure may systematically change with accretion rate.